Hiroaki Shimokawa Selected Research

Biomarkers (Surrogate Marker)

1/2023	Plasma ANGPTL8 Levels and Risk for Secondary Cardiovascular Events in Japanese Patients With Stable Coronary Artery Disease Receiving Statin Therapy.
12/2020	Recent Advances in Vascular Imaging.
1/2020	PIM1 (Provirus Integration Site For Moloney Murine Leukemia Virus) as a Novel Biomarker and Therapeutic Target in Pulmonary Arterial Hypertension: Another Evidence for Cancer Theory.
1/2020	Cyclophilin A as a biomarker for the therapeutic effect of balloon angioplasty in chronic thromboembolic pulmonary hypertension.
12/2019	Identification of Adipsin as a Novel Prognostic Biomarker in Patients With Coronary Artery Disease.
12/2019	Diagnostic and Prognostic Significance of Serum Levels of SeP (Selenoprotein P) in Patients With Pulmonary Hypertension.
1/2018	Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension: Possible Novel Therapeutic Target.
1/2017	Prognostic Impacts of Plasma Levels of Cyclophilin A in Patients With Coronary Artery Disease.
1/2016	Deletion of LR11 Attenuates Hypoxia-Induced Pulmonary Arterial Smooth Muscle Cell Proliferation With Medial Thickening in Mice.
8/2015	2015 ATVB Plenary Lecture: translational research on rho-kinase in cardiovascular medicine.

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Hiroaki Shimokawa Research Topics

Disease

71	Heart Failure 03/2024 - 03/2002
49	Cardiovascular Diseases (Cardiovascular Disease) 03/2023 - 03/2002
45	Myocardial Infarction 12/2022 - 05/2004
41	Pulmonary Hypertension 01/2021 - 07/2002
40	Myocardial Ischemia (Ischemic Heart Diseases) 12/2023 - 01/2002
31	Coronary Artery Disease (Coronary Atherosclerosis) 08/2023 - 01/2002
31	Inflammation (Inflammations) 01/2023 - 02/2002
28	Spasm (Spasms) 02/2022 - 02/2002
28	Hypertension (High Blood Pressure) 01/2022 - 04/2002
26	Stroke (Strokes) 12/2022 - 02/2002
24	Hypoxia (Hypoxemia) 01/2021 - 07/2002
23	Coronary Vasospasm (Coronary Artery Vasospasm) 01/2023 - 03/2002
21	Ischemia 09/2021 - 07/2003
21	Pulmonary Arterial Hypertension 01/2021 - 01/2005
20	Fibrosis (Cirrhosis) 01/2021 - 02/2002
19	Shock 01/2022 - 11/2004
17	Arteriosclerosis 01/2016 - 02/2002
15	Thrombosis (Thrombus) 01/2022 - 04/2002
15	Atherosclerosis 10/2018 - 03/2002
14	Atrial Fibrillation 11/2023 - 12/2016
11	Reperfusion Injury 01/2016 - 08/2004
10	Neoplasms (Cancer) 12/2023 - 11/2010
10	Hemorrhage 06/2023 - 02/2008
10	Hypertrophy 01/2021 - 10/2003
10	Cardiomyopathies (Cardiomyopathy) 01/2021 - 05/2002
9	Unstable Angina 11/2023 - 01/2016
9	Angina Pectoris 01/2023 - 01/2005
9	Chest Pain (Chest Pains) 01/2023 - 03/2002
8	Pathologic Constriction (Stenosis) 01/2022 - 04/2002
8	Ventricular Tachycardia 12/2021 - 01/2015
8	Diabetes Mellitus 01/2020 - 10/2004
7	Cognitive Dysfunction 05/2024 - 01/2017
7	Ventricular Remodeling 01/2018 - 05/2004
7	Vascular Remodeling 01/2018 - 12/2002
7	Vascular Diseases (Vascular Disease) 11/2010 - 02/2002
6	Death (Near-Death Experience) 01/2022 - 09/2010
6	Cardiac Sudden Death (Sudden Cardiac Arrest) 12/2021 - 05/2004
6	Cardiomegaly (Heart Hypertrophy) 05/2016 - 01/2005
5	Alzheimer Disease (Alzheimer's Disease) 05/2024 - 09/2018
5	Stable Angina 01/2023 - 01/2005
5	Tachycardia (Tachyarrhythmias) 01/2023 - 05/2007
5	Acute Coronary Syndrome 11/2021 - 04/2002
5	Ischemic Stroke 09/2021 - 12/2016
5	Embolism (Embolus) 09/2021 - 12/2016
5	Atherosclerotic Plaque (Atheroma) 12/2020 - 04/2002
5	Infarction (Infarctions) 01/2018 - 07/2004
5	Right Ventricular Hypertrophy 06/2014 - 02/2004
4	Microvascular Angina (Cardiac Syndrome X) 12/2022 - 01/2003
4	Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy) 10/2022 - 09/2018
4	Ventricular Fibrillation 12/2021 - 04/2009
4	Coronary Stenosis (Coronary Artery Stenosis) 01/2021 - 03/2003

Drug/Important Bio-Agent (IBA)

80	rho-Associated KinasesIBA 01/2023 - 02/2002
29	fasudil (AT 877)IBA 12/2019 - 04/2002
25	Nitric Oxide (Nitrogen Monoxide)FDA Link 11/2023 - 02/2002
19	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 03/2024 - 07/2003
17	Proteins (Proteins, Gene)FDA Link 03/2024 - 07/2002
17	Vasodilator Agents (Vasodilators)IBA 01/2023 - 07/2003
17	Acetylcholine (Acetylcholine Chloride)FDA Link 02/2022 - 03/2002
14	Brain Natriuretic Peptide (Natrecor)FDA Link 03/2024 - 09/2008
14	Biomarkers (Surrogate Marker)IBA 01/2023 - 05/2008
13	Nitric Oxide Synthase (NO Synthase)IBA 11/2023 - 02/2004
13	omega-Chloroacetophenone (Mace)IBA 01/2023 - 09/2010
12	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 05/2024 - 02/2002
10	CytokinesIBA 03/2024 - 05/2002
10	Protein Isoforms (Isoforms)IBA 11/2023 - 07/2005
10	LipidsIBA 08/2023 - 09/2010
10	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 05/2019 - 07/2003
10	hydroxyfasudilIBA 02/2016 - 02/2002
10	Angiotensin IIIBA 05/2015 - 02/2002
10	Monomeric GTP-Binding ProteinsIBA 01/2015 - 02/2002
9	MonocrotalineIBA 01/2021 - 02/2004
9	NitratesIBA 08/2020 - 10/2004
9	Reactive Oxygen Species (Oxygen Radicals)IBA 08/2020 - 02/2003
8	Cyclophilin AIBA 01/2021 - 11/2010
7	RivaroxabanIBA 11/2023 - 12/2016
7	pitavastatin (itavastatin)FDA Link 08/2023 - 01/2018
7	LDL CholesterolIBA 08/2023 - 09/2010
7	Calcium Channel Blockers (Blockers, Calcium Channel)IBA 01/2023 - 10/2004
7	Lactic Acid (Lactate)FDA LinkGeneric 01/2021 - 03/2002
6	Messenger RNA (mRNA)IBA 11/2023 - 07/2002
6	CreatinineIBA 01/2021 - 09/2004
6	Erythropoietin FDA Link 10/2011 - 03/2006
5	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 03/2024 - 03/2009
5	pro-brain natriuretic peptide (1-76)IBA 03/2024 - 01/2019
5	AnticoagulantsIBA 12/2023 - 11/2008
5	Angiotensin Receptor AntagonistsIBA 01/2022 - 07/2013
5	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 08/2020 - 09/2006
5	Serotonin (5 Hydroxytryptamine)IBA 02/2017 - 02/2002
5	endothelium-dependent hyperpolarization factor (EDHF)IBA 01/2015 - 05/2005
4	LDL Receptors (LDL Receptor)IBA 01/2021 - 09/2010

Therapy/Procedure

78	Therapeutics 05/2024 - 09/2002
20	Extracorporeal Shockwave Therapy 07/2023 - 11/2004
16	Percutaneous Coronary Intervention 06/2023 - 01/2005
10	Stents 03/2020 - 04/2002
9	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 02/2022 - 04/2009
6	Catheter Ablation 06/2021 - 01/2015
6	Ligation 01/2019 - 12/2002
5	Drug-Eluting Stents 01/2021 - 01/2012
5	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 10/2011 - 09/2004
4	Secondary Prevention 02/2022 - 02/2012